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Targeted Cancer MDx

Through genomic research, we continue to learn more about the complexity of cancer. While cancer continues to be identified by its location in the body (lung, breast, blood, etc.), we have learned that a more accurate way to evaluate cancer treatment is through examination of the underlying changes or mutations which drive cancer development and progression. Those mutations are not limited to location and, in many instances, have very little correlation with the location.  Understanding the core genetic mutations which drive cancer progression allows clinicians to replace more traditional treatments with newer, less toxic, therapies that target those specific mutations. 

GenOnc Panel 1 - ACTIONABLE  Solid Tumor (23 Genes)

Targets key regions of 23 genes identified by the National Comprehensive Cancer Network (NCCN), College of American Pathologists (CAP), and American Society of Clinical Oncology (ASCO) to be clinically actionable somatic mutations in solid tumors

Exons
BRAFPDGFRAEGFR (ERBB1), KRASNRASKIT (CD117).

Hotspots
AKT1ALKCTNNB1ERBB3ESR1 (ERα), FOXL2GNA11GNAQIDH1IDH2METRAF1RET.

Whole Coding Region
ERBB2 (HER-2, NEU), PIK3CA (p110-alpha), TP53 (p53).

GenOnc Panel 2 – COMPREHENSIVE (275 genes)

The GenOnc Comprehensive Cancer Panel is the most comprehensive cancer gene panel available. Encompassing over 50% of the Welcome Trust Sanger Institute Cancer Gene Census, this 409 gene panel targets key tumor suppressor genes and oncogenes that are the most frequently cited and most frequently mutated in cancer. The panel includes genes that function in growth factor and cytokine responses, signaling cascades, apoptosis, DNA repair, cell cycle regulation, transcription regulation, and inflammatory response pathways

GenOnc Panel 3 - PREDISPOSITION   (145 genes)

Predisposition Targeted Panel is a multiplexed PCR-based assay for targeted enrichment of the coding (exonic) regions of the 145 genes commonly mutated in 88 inherited oncogenic diseases

Cancer Predisposition
Cancers: AKT1APCATRBLMBRCA2BRIP1BUB1BCHEK2 (RAD53), EPCAMFANCAFANCBFANCCFANCD2FANCEFANCFFANCGFANCIFANCLFANCMHRASLIG4MLH1MSH2MSH6PALB2PIK3CA (p110-alpha), PMS2PRKAR1APTENSLX4 (BTBD12), TP53 (p53), VHL.
Bone: EXT1EXT2MTAPRECQL4TP53 (p53).
Hereditary Breast-Ovarian: BARD1BRCA1BRCA2CHEK2 (RAD53), RAD51B (RAD51L1), RAD51CRAD51D (RAD51L3).
Colorectal: APCAXIN2GALNT12MLH3MUTYHPOLD1POLE.
Endocrine: AIPCDC73CDKN1B (P27KIP1), CYP21A2GLI3MAXMEN1NDUFA13NTRK1PDE11APRKAR1ARETTMEM127TP53 (p53), VHL.
Gastrointestinal Tract: ASCC1BMPR1A (ALK3), CDH1 (E-Cadherin), KIT (CD117), MSR1PDGFRAPTENRHBDF2SDHCSMAD4 (MADH4), STK11 (LKB1).
Head & Neck: CYLDDKC1RTEL1TERCTERTTINF2TSC1TSC2.
Hematopoietic: ATMCEBPAGATA2KLHDC8BLYSTMRE11ANBN (NBS1), RAD50RUNX1(AML1), SBDSTERTWAS.
Kidney: DIS3L2FHFLCNMETMITFPOU6F2WT1.
Liver: FAHHFEUROD.
Nervous System: ALKGPC3KIF1BNF1NF2PRKAR1ARB1PHOX2BSDHASDHAF2SDHBSDHDSMARCA4SMARCB1SUFU.
Skin: BAP1CDK4CDKN2A (p16INK4a), CYLDDDB2ERCC2 (XPD), ERCC3 (XPB), ERCC4ERCC5ERCC6FHFLCNGLMNMC1RMITFMSH2POLHPTCH1PTCH2RSPO1TGFBR1(ALK5), TMC6TMC8XPAXPCXRCC3.
Soft Tissue: ANTXR1ANTXR2CD96ESCO2KDR (VEGFR3), PTENWRN.
Other Cancers: BRCA2CHEK1DICER1EHBP1EPHB2MSMBMSR1PALB2PALLDRNASEL.